Chronic eosinophilic leukemia with unique chromosomal abnormality, t(5;12) (q33;q22)

Chronic eosinophilic leukemia with a unique translocation.

We report a case of chronic eosinophilic leukemia in a 9 year old girl who presented with anemia, thrombocytopenia, leucocytosis (mostly dysplastic eosinophils), lymphadenopathy and hepatosplenomegaly. There was no increase in blasts but myelofibrosis was seen in the bone marrow. A previously unreported translocation 46,XX,t(1;4)(q24;q35), was found on cytogenetic analysis and involvement of th...

Chromosomal Abnormality in Men with Impaired Spermatogenesis

Chronic eosinophilic leukemia

Chronic eosinophilic leukaemia (CEL) is a rare myeloproliferative disorder of unknown etiology characterized by an autonomous, clonal proliferation of eosinophilic precursors resulting in persistently increased number of eosinophils in the peripheral blood and bone marrow. There is vaguely overlapping clinico – pathological picture of CEL with idiopathic hypereosinophilic syndrome (HES) which o...

Isodicentric Philadelphia chromosome: an uncommon chromosomal abnormality in the chronic phase of chronic myeloid leukemia (CML)

An isodicentric Philadelphia chromosome is an uncommon finding previously described as a secondary chromosomal abnormality in accelerated- or blast-phase of chronic myeloid leukemia (CML) with resistance to imatinib mesylate or dasatinib. Here, we present a case with idic(Ph) chromosome identified at initial diagnosis in a patient with chronic-phase CML.

Chronic eosinophilic leukemia with FIP1L1-PDGFRA rearrangement

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Table 1. Summary of Korean cases of chronic eosinophilic leukemia with FIP1L1-PDGFRA rearran...